Principal Scientist, Discovery-Oncology

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com . As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit. Job Function: Discovery & Pre-Clinical/Clinical Development Job Sub Function: Biological Research Job Category: Scientific/Technology All Job Posting Locations: Spring House, Pennsylvania, United States of America Job Description: About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. About Oncology Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. We are searching for the best talent for 2 Principal Scientists, in Oncology Discovery, Innovative Medicine, located in Spring House, PA Johnson & Johnson Innovative Medicine Oncology Discovery is seeking 2 outstanding and highly motivated scientists to join our team focused on creating best-in-class therapeutics for prostate cancer treatment. These positions will be for experienced individual contributors and subject matter experts responsible for developing robust pharmacology packages for T-cell engagers (TCEs) and small molecule therapeutics. Candidates should have expertise in cancer biology or immunology, and the mechanisms required to trigger robust anti-tumor response. Additionally, candidates must demonstrate direct experience in small/large molecule design and/or combination strategies to overcome solid tumor microenvironment. Furthermore, knowledge of current assays required to characterize optimal T-cell functional performance is a requirement. Successful candidates are expected to drive future innovation around TCE design by identifying enabling technologies through either internal or external efforts. Candidates must demonstrate prior program leadership experience in industry and must have a track record of excellence in managing projects and collaborating effectively with colleagues in other functional areas. The Principal Scientists will: Work with and/or lead a team of scientists in nominating candidates for discovery portfolio programs Plan, develop and execute state-of-the-art assays that enable the identification of optimal TCE candidates to maximize therapeutic potential and durability in solid tumors Partner with leaders in other therapeutic areas to select optimal binders, molecular configuration and delivery strategies While delivering on prioritized goals, foster a culture of scientific excellence and innovation Eliminate barriers to collaboration across workstreams and functions by encouraging a culture of open communication and transparency Contribute to intellectual property, public presentations, and manuscript writing. Identify partnerships in academia to compliment key research initiatives Mentor junior scientists on the team, and promote personal and professional development Qualifications Demonstrate matrixed leadership behavior and capabilities including design, guide, and perform highly complex experiments, accurately interpret data, and effectively communicate impact to stakeholders through formal and informal disclosures Ph.D. in Cancer Biology and/or Immunology with at least 6+ years of industry experience leading Discovery programs and teams, or performing progressively advanced duties at the Principal Scientist level, or the equivalent training/experience Hands-on experience with TCE or small molecule therapeutics, and a track record of successfully advancing therapeutic candidates through lead selection and IND-enabling activities Possess drug development knowledge Demonstrate track record of innovating in the drug discovery space. Constantly seek new technologies, processes, and techniques. Able to identify, implement, and master new models and improvements Able to integrate diverse subject areas to achieve research objectives Experienced supporting research collaborations with academic institutions, industry partners and research institutions Possess highly effective verbal and written communication skills Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We