Vice President, Head of Transactions and Partnering

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide. Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.The Opportunity: The Vice President, Head of Transactions and Partnering is a senior leader within the Corporate Development organization and will play a key role in the evaluation, structuring, negotiation, and execution of strategic business development transactions that support Revolution Medicines’ corporate and portfolio objectives. Reporting to the Head of Corp Development, this individual is a leader and principal negotiator across licensing, collaboration, co-development, alliance, option, platform, and other business development agreements. The role partners closely with executive leadership and stakeholders across Research, Development, Commercial, Finance, Legal, Intellectual Property, and Executive Management to shape strategy and advance high-priority opportunities from initial assessment through execution. The successful candidate will bring deep transaction expertise, strong business judgment, exceptional negotiation skills, and demonstrated people leadership. This role will lead a high-performing transactions and partnering team with the capabilities, operating model, and culture to support evolving strategic priorities; attract, develop, empower, and retain exceptional talent; and establish clear roles, standards, and ways of working. Through a culture of collaboration, accountability, learning, and excellence, they will help establish and execute partnerships that accelerate innovation, expand capabilities, and create long-term value for patients and shareholders. Responsibilities Transaction Leadership and Execution Lead transaction activities, advancing prioritized opportunities from evaluation through execution while ensuring resources are focused on the highest-value opportunities. Serve as the senior transaction lead for the most complex and strategically significant business development opportunities, while developing and empowering team members to lead transactions with increasing scope and independence. Structure, negotiate, and execute a broad range of transactions, including licensing, collaboration, co-development, alliance, option, platform, and other strategic agreements. Lead transaction processes from initial engagement through confidentiality agreements, term sheet development, definitive agreement negotiation, and transaction closing. Develop creative transaction structures that appropriately balance strategic objectives, economics, operational considerations, and risk allocation. Identify transaction risks and develop practical solutions that facilitate successful deal execution while protecting the company's interests. Negotiation and Deal Structuring Serve as Revolution Medicines' senior negotiator for strategic business development transactions and establish a consistent, high-quality approach to negotiation across the transactions team. Partner closely with finance and legal/transaction counsel to develop transaction structures, review and negotiate definitive agreements, and drive successful deal execution. Collaborate with FP&A, commercial, competitive intelligence, business development team members to evaluate transaction economics, valuation analyses, and investment considerations. Lead negotiations involving scientific, clinical, commercial, intellectual property, operational, and financial elements of complex transactions. Develop and execute negotiation strategies that maximize value creation while preserving long-term partnership success. Cross-Functional Transaction Management Lead and oversee cross-functional transaction teams, aligning scientific, clinical, commercial, financial, intellectual property, and legal stakeholders throughout the evaluation and negotiation process, and coach team members in effective cross-functional leadership. Partner closely with the Search & Evaluation function to coordinate diligence activities and ensure comprehensive assessment of strategic, scientific, operational, legal, and financial considerations. Drive stakeholder alignment and facilitate efficient decision-making across multiple functions and organizational levels. Establish clear transaction plans, governance processes, timelines, and accountability to support successful execution. Collaborate with Alliance Management function in negotiations and structuring phase to enable a seamless handoff to operationalizing relationships after agreement execution. Governance and Executive Decision Support Drive opportunities from initial contact all the way through to executive decision-making, including triaging, evaluation, identification of internal champion(s) and cultivation of internal support, and navigation of transaction governance processes Prepare and present transaction recommendations, strategic assessments, valuation analyses, and key negotiation considerations to senior leadership and, as appropriate, board-level audiences. Clearly communicate strategic rationale, transaction economics, risks, alternatives, and key deal terms to support informed decision-making. Partner with Business Development and executive leadership to evaluate strategic opportunities, shape recommendations, and support timely, high-quality decisions on capital and partnership priorities. External Relationship Management Build and maintain senior-level relationships across the biotechnology, pharmaceutical, academic, and investment communities. Represent Revolution Medicines in partnering discussions, industry conferences, and external business development engagements. Support opportunity sourcing and relationship development efforts in partnership with Business Development leadership. Establish a strong external network that enhances the company's access to innovative science, technologies, and strategic opportunities. Team and Organizational Leadership Build, lead, and scale a high-performing transactions and partnering team aligned to the company’s strategic priorities and evolving business development needs. Recruit, develop, coach, and retain exceptional talent; set clear expectations and accountabilities; create meaningful development opportunities; and build succession and leadership depth within the team. Create an inclusive, high-performance team culture grounded in collaboration, accountability, excellence, sound judgment, and integrity. Establish scalable transaction processes, governance practices, tools, and operating rhythms that enable the team to execute with speed, rigor, consistency, and clear accountability. Allocate team resources across opportunities, balance hands-on leadership with effective delegation, and ensure the organization has the capabilities and capacity required to deliver against the partnering agenda. Required Skills, Experience and Education: Advanced degree in life sciences, medicine, pharmacy, business, or a related field; MBA, PhD, MD, PharmD preferred. 15+ years of relevant experience in biotechnology or pharmaceutical business development, transactions, corporate strategy, or related disciplines, with increasing scope and leadership responsibility. Demonstrated track record of leading and executing multiple complex, hig