Senior Scientist - Discovery Analytical Research (On-site)

Job Description We are seeking a highly motivated and innovative Senior Scientist to join our Discovery Analytical Research (DAR) group within the Analytical Enabling Capabilities (Analytical R&D) organization in Rahway, NJ. In this pivotal role, you will apply state-of-the-art analytical platforms, separation sciences, high-resolution mass spectrometry, automation and digital tools to accelerate drug discovery pipelines and directly influence the design and selection of next-generation therapeutic candidates. Working at the dynamic interface between discovery and early development, you will lead analytical method development across chemical modalities including small molecules, macrocyclic peptides, complex linker-payloads, and synthetic intermediates. You will collaborate closely with cross-functional teams to solve complex scientific challenges, champion novel analytical technologies, and drive data-backed candidate selection at discovery interface. Primary Responsibilities Design, optimize, and execute robust chromatographic separation methodologies, including HPLC, UHPLC, Supercritical Fluid Chromatography (SFC), and Size Exclusion Chromatography (SEC) integrated with multi-detector systems (UV-Vis, CAD, and MS) to characterize the critical physicochemical properties of small molecules and peptides. Serve as a technical subject matter expert in High-Resolution Mass Spectrometry (HRMS) and tandem mass spectrometry (MS/MS) for structural confirmation and de novo sequence/structure elucidation of complex macrocyclic peptides and synthetic small molecules. Contribute to evaluation and implementation of next-generation measurement technologies and high-throughput workflows and automated liquid handling systems ( e.g. , Tecan, Bravo, Lynx). Contribute to continuous improvement in laboratory efficiency by implementing automated data-processing and digital workflows that accelerate analytical sample processing, database curation, and data visualization. Partner proactively with discovery teams, championing technical initiatives that elevate departmental capabilities, presenting scientific findings/updates at project meetings. Uphold the highest standards of data integrity, electronic laboratory notebook (ELN) documentation, and Good Documentation Practices (GDP) in accordance with organizational policies. Education & Experience Requirements Ph.D. in Analytical Chemistry, Biochemistry, or a related scientific discipline; OR Master’s Degree (M.S.) in Analytical Chemistry or a related scientific discipline with 7&#43; years of relevant biopharmaceutical industry experience. Required Experience and Skills Deep expertise in HPLC/UHPLC method development and LC-MS characterization applied to synthetic small molecules and cyclic peptides. Experience in MS-based structural confirmation, and de novo elucidation of small molecules and complex peptides. Hands-on experience operating, tuning, and troubleshooting modern Q-TOF, Orbitrap mass spectrometers (e.g., Thermo, Sciex, Waters, or Agilent). Demonstrated capability to balance multiple project priorities independently within tight timelines while maintaining scientific rigor. Proven capability to drive technical initiatives, and collaborate effectively across multifunctional project teams. Excellent written and verbal communication skills, underscored by a strong record of first-author publications in peer-reviewed journals and presentations at major scientific conferences. Preferred Experience and Skills Experience integrating automated liquid handlers ( e.g. , Tecan, Agilent Bravo) into high-throughput analytical workflows. Familiarity with automated data compilation, scripting, or analytical data processing software ( e.g. , Python/R for analytical data analysis). Hands-on experience with Acoustic Ejection Mass Spectrometry (AEMS / Echo-MS) or high-throughput mass spectrometry (HT-MS) platforms. EligibleforERP Required Skills: Analytical Chemistry, Analytical Method Development, Analytical Testing, Analytical Thinking, Biochemical Assays, Biochemistry, Chromatographic Techniques, Experimental Methods, High-Performance Liquid Chromatography (HPLC), Liquid Chromatography (LC), Liquid Chromatography-Mass Spectrometry (LC-MS), Mass Spectrometry (MS) Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights <p style="text-align:le