Principal Scientist, Lab Platform Disruptive Technologies

Job Description We are on a quest for cures and are committed to be the world’s premier, most research-intensive biopharmaceutical company. Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines. Discovery Biologics Disruptive Technologies is seeking a talented and experienced scientist to lead the development and deployment of next-gen lab-based experimental technologies to enable rapid, data-driven biologics discovery. This individual will identify and translate emerging, literature-supported technologies into scalable internal capabilities, with a focus on multiplying both the scale and speed of quantitative data generation (e.g., binding measurements) to advance therapeutic programs via GenAI/ ML-driven discovery and iterative design-make-test cycles. The role includes leading a team with expectation for strong hands-on contribution to method development, and will be accountable for driving measurable program and broader organizational impact. The role is based out of our Cambridge, MA facility. Key Responsibilities Develop and mature rapid , quantitative and high-throughput lab-based capabilities for biologics hit identification an d optimization Build and execute a technology platform roadmap for arrayed and pooled technologies, from proof-of-concept through widespread program adoption Partner effectively with computational protein engineering and data science groups toward efficient, integrated next-gen discovery workflows Drive capability improvements in data richness, speed , throughput Lead a talented team of lab-based scientists As a hands-on individual contributor, realize and maximize program impact of emerging technologies Collaborate effectively across geography and reporting lines Establish rigorous benchmarks (e.g. throughput, speed, reproducibility , data quality ) and success criteria Qualifications & Experience PhD in Biochemistry, Bioengineering, Chemical Biology, or related field with 7&#43; years directly relevant industry experience ; MS or BS with 12&#43; years industry experience. Experience developing large-scale, high throughput quantitative experimental methods for biologics discovery Experience translating published or externally developed methods into demonstrably valuable internal capabilities Proven leadership track record Required Skills Demonstrated expertise advancing validated assays and methods toward broad organizational impact Deep hands-on expertise in one or more of: Quantitative p ooled binding assays (10k&#43; sequences) Rapid and high throughput advanced endpoint assays ( e.g. cell-based function, stability, localization, etc) Lab-on-chip technologies and protein arrays M icrofluidics Proven succes s in l eadership , talent development and mentorship Strong understanding of biochemistry and biophysical characterization methods Cross-function project leadership track record Strong ability to collaborate across reporting lines, especially with protein engineers and data scientists Preferred Skills Strong demonstrated understanding of protein structure-function relationships E xperience applying in vitro transcription and translation (IVTT) </l