Sr Staff Software Engineer

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Summary At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Sequencing has moved genomics from single studies to population scale. Multi-million-sample cohorts, linked phenotypes and multi-omic data are now generated faster than most organizations can analyze them. Our team builds the data platform and the analytical applications that turn these assets into products: a cloud-native lakehouse for genomic and phenotypic data, large-scale statistical genetics pipelines that run reliably at population scale, and the APIs and user interfaces that let scientists ask questions of billions of records and get answers in seconds. We are looking for a Sr. Staff Software Engineer for this effort in Singapore: someone who can take state-of-the-art analytical methods and turn them into scalable, high-performance, commercial software, and who can work fluently across bioinformatics scientists, cloud infrastructure engineers, and product management. You will work with a globally distributed team, prototyping quickly, demonstrating early, and iterating toward a releasable product. Responsibilities Turn advanced statistical genetics methods (for example, genome-wide and phenome-wide association testing for both common and rare variants) from prototypes into high-performance, scientifically accurate, commercially releasable products. Design and implement analysis pipelines that scale to millions of samples on a cloud-native lakehouse, and establish the standardized, reusable design pattern for low-latency analysis on open table formats at petabyte scale. Deliver the APIs, web UI and natural-language/agentic query interfaces through which scientific users explore association results and cohort/phenotype data interactively at scale. Own the operability and unit economics of the platform: orchestrate, monitor, debug and cost-optimize workloads spanning millions of concurrent jobs, designing for fault tolerance and reproducible results. Partner with bioinformatics scientists, cloud infrastructure teams and product management to translate scientific and customer needs into a product architecture and credible delivery plan aligned with the platform and data business strategy, applying a clear view of what distinguishes a commercial-grade offering from research and open-source community tooling. Set technical direction and raise engineering standards through design review, mentorship and hands-on contribution, prototyping and iterating rapidly with a customer-first mindset across a globally distributed team. Requirements Degree in Computer Science / Engineering / Bioinformatics / Mathematics or a related field. Demonstrated experience designing and delivering large-scale, data-analysis production software in the cloud (AWS, Azure, or GCP), including containerization (Docker), orchestration, infrastructure automation, and CI/CD. Strong experience with modern data lake / lakehouse architectures, including open table format internals rather than usage alone: Apache Iceberg or Delta Lake table specifications, catalog services, snapshot lifecycle, partitioning and pruning strategy, compaction, and schema evolution, over columnar storage (Parquet) with distributed query engines (for example Spark, Trino, Databricks). Solid algorithms and systems engineering foundation, with proven ability to implement performance-critical code in a compiled language such as C/C++, including concurrency, memory management, vectorization and SIMD, and work with columnar in-memory formats and vectorized engines such as Apache Arrow, DuckDB, or Velox. Proven track record of profiling and optimizing end-to-end systems for runtime, memory, I/O and cloud cost at large scale, and of designing for horizontal scalability. Proficiency in Python for rapid prototyping, data analysis, and productionized tooling, with familiarity with the scientific and ML/DL library ecosystem. Experience designing and operating distributed batch and workflow systems that manage very large numbers of concurrent jobs, including metrics, tracing and structured logging, retry, checkpointing and idempotency, and failure triage at million-task scale. Experience with scientific workflow languages and engines (for example Nextflow, WDL, CWL) and with execution on cloud batch or Kubernetes. Experience designing and delivering service APIs with an API-first approach: REST or gRPC interface design, versioning and backward compatibility, and multi-tenant access patterns; plus enough full-stack fluency to partner on (or build) modern web front ends and to hold strong opinions on UI/UX for data-heavy scientific applications. Experience validating numerically and statistically sensitive software: concordance testing against reference implementations, calibration checks, benchmark suites, versioned reference data, and end-to-end reproducibility. Proven technical leadership and influence at senior level, with strong verbal and written communication skills, and the ability to self-manage and manage interdisciplinary relationships. Demonstrated experience using AI tooling to plan, manage and accelerate the full software development lifecycle, and to materially increase engineering productivity and quality. Experience / Education Sr. Staff Software Engineer: Typically requires a minimum of 12 years of related experience with a Bachelor's degree; or 8 years and a Master's degree; or a PhD with 5 years experience; or equivalent experience. Desired Working knowledge of statistical genetics and population genomics: genome-wide and phenome-wide association studies, common and rare variant analysis (including gene-based burden and aggregate tests), mixed-model and whole-genome regression approaches, and the standard data formats and quality control practices of the field (VCF/gVCF, PLINK, BGEN, summary statistics, cohort and phenotype definition, ancestry and relatedness handling). Hands-on experience with genomics-native storage and query stacks such as TileDB / TileDB-VCF, Hail, GLOW, or GenomicsDB. Experience delivering commercial or clinical-grade genomics or life-science data products, including taking an internal or research tool through to a commercially released product, and a clear understanding of the differences in philosophy, obligations and trade-offs between commercial productization and academic, non-profit or research-community tooling. Familiarity with techniques for low-latency query over very large result sets: precomputed summary indices