Principal Infrastructure Program Manager | Onsite San Diego HQ

Who We Are: Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com , and follow the company on LinkedIn , X , Facebook and YouTube . ( *in collaboration with AbbVie ) About the Role: The Principal IT Infrastructure Program Manager is a senior execution leader responsible for driving the successful delivery and value realization of complex, enterprise-scale technology initiatives. Operating within the Value Management Office (VMO), this role ensures disciplined program execution across infrastructure, cloud, cybersecurity, and enterprise platforms. This individual brings deep infrastructure domain expertise and structured program management rigor to lead cross-functional initiatives that are critical to business performance, regulatory compliance, and operational scalability. The role is highly execution-focused, emphasizing governance, risk management, stakeholder alignment, and measurable outcomes. Impact: Lead enterprise-wide infrastructure transformation initiatives that enable business growth and operational excellence Ensure secure, compliant, and scalable delivery of critical technology platforms in a regulated environment Drive transparency, accountability, and value realization across complex, multi-stakeholder programs Strengthen alignment between IT strategy and business objectives through disciplined execution _ Your Contributions (include, but are not limited to): Enterprise Infrastructure & Program Delivery Lead large-scale, multi-domain initiatives including cloud migrations, network modernization, data center upgrades, and managed service transitions Drive structured program execution including milestones, dependencies, RAID logs, and executive reporting Ensure delivery is on time, within scope, and aligned to enterprise roadmaps and business goals Translate technical complexity into clear business impact and decision-ready insights Infrastructure & Managed Services Design and implement scalable L1/L2 managed service models Lead vendor onboarding, transition planning, and operational readiness Establish SLA/KPI governance and service performance management frameworks Drive integration between infrastructure monitoring platforms and ITSM systems (e.g., ServiceNow) Implement runbooks, escalation models, and operational accountability structures Governance, Risk & Compliance Establish and maintain program governance cadence including executive-level reporting Identify and mitigate cross-domain risks across infrastructure, cybersecurity, and compliance Ensure validation, regulatory, and security requirements are embedded into delivery plans Maintain documentation and traceability to support audit readiness in regulated environments Vendor & Financial Management Manage strategic vendor relationships across cloud, network, and infrastructure providers Drive vendor accountability through structured governance forums Track budgets, forecast financial impact, and support cost optimization initiatives Ensure resource and capacity planning aligns with program delivery needs Business & Stakeholder Partnership Partner with IT and business leaders to align infrastructure solutions with enterprise needs Translate business requirements into scalable, compliant technology solutions Drive alignment across Cybersecurity, Architecture, Engineering, and Operations teams Communicate effectively with executive stakeholders to influence decisions and remove barriers Requirements: Bachelor’s degree in Computer Science, Information Technology, or related field with 6+ years of IT experience in a pharmaceutical/biotech environment with FDA regulatory exposure , OR Master’s degree in a related field with 4+ years of relevant experience Strong experience managing enterprise infrastructure programs across cloud, network, and data center environments Proven experience leading system/platform migrations and multi-cloud hybrid implementations Experience supporting validated applications in regulated environments Strong program and project management expertise (PMP certification preferred or in progress) Experience with ITSM integration and service delivery (e.g., ServiceNow) Demonstrated ability to manage risk, drive structured escalation, and lead complex cross-functional programs Strong financial acumen with experience managing budgets and forecasting Preferred: PMP and/or ScrumMaster certification Trained in Agile Frameworks Experience working with enterprise infrastructure vendors and managed service providers Change advisory board experience Advanced knowledge of infrastructure technologies including cloud platforms, networking, and platform engineering Experience operating in highly matrixed, global organizations Neurocrine Biosciences is an