Associate Director, Protein Sciences

Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. By harnessing advancements in genetics, immunology and neuroscience, we are pioneering the development of potential therapies to counteract the devastating progression of neurodegeneration. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history. Key Goals & Accountabilities Advance our Protein Sciences strategy. Lead internal and external Protein Sciences activities to deliver high-quality proteins and conjugates that support Alector’s research and development programs. Build capabilities for emerging modalities. Establish and evolve protein purification, conjugation, and analytical capabilities to advance antibody–oligonucleotide conjugates and other emerging program needs. Develop the team and scale our impact. Manage, mentor, and develop a small Protein Sciences team while providing hands-on technical guidance and effectively leveraging external CRO partners to meet program priorities and timelines. Accelerate programs from research toward development. Partner across discovery, platform, development, CMC, and other teams to advance lead candidates, ensuring production and analytical strategies address developability, process viability, and manufacturing considerations. Innovate how we work. Integrate new technologies, including AI and large language models, into Protein Sciences workflows to accelerate programs, generate insights, and use resources more effectively. Required Qualifications PhD in biochemistry, molecular biology, biophysics, protein sciences, or a related scientific discipline with 8+ years of relevant biotechnology or pharmaceutical industry experience, or an equivalent combination of MS/MSc with 10+ years of relevant industry experience. Significant biotechnology or pharmaceutical industry experience in protein sciences, therapeutic antibodies, or related biologic modalities, including experience leading and developing scientific staff. Demonstrated history of advancing therapeutic proteins or antibodies from research and discovery toward development, including familiarity with developability and CMC considerations. Broad scientific expertise across protein production, purification, characterization, and analytical methods, with hands-on experience using FPLC/AKTA and familiarity with HPLC, mass spectrometry, or related analytical platforms. Active user of large language models (LLMs), with a strong interest in applying evolving AI technologies to scientific research and drug development. Preferred Qualifications Hands-on experience with antibody–oligonucleotide conjugates or closely related conjugated biologic modalities. Experience managing external CRO partnerships; experience working with WuXi Biologics or similarly fast-paced global CROs is a plus.