Analytical Chemistry - Platform and Mass Spectrometry principal scientist

Business Introduction At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together. Find out more: Our approach to R&D Job Purpose We are seeking a P rinc ip al S cientist to provide expert scientific and technical contribution, to the modernisation and evolution of discovery Analytical Chemistry platforms supporting developing and complex therapeutic modalities. This role supports the evolution of the current analytical LCMS platform capability beyond the current small-molecule portfolio, contributing to robust, scalable, and future- proof LCMS analysis of divalent small molecules, drug conjugates including Warhead Linker Payloads for Antibody Drug Conjugates (WLPs for ADCs), peptides and oligonucleotides . The position plays an important role in ensuring analytical platforms are positioned to meet near-term pipeline demands, while maintaining the highest standards of scientific excellence. The successful candidate will be a hands-on mass spectrometry specialist , combining deep technical expertise in LC-MS/HRMS with a good working knowledge of platform-level analytical strategy. Through hands-on method development, troubleshooting, and application of mass spectrometry and complementary chromatographic techniques - alongside contribution s to modernisation existing capabilities and introduc ing new technologies to our auto mation platform for conjugation chemistry - this role will s hape the future of analytical platform delivery for emerging modalities. This is a Scientific role at G7 grade and will require close working relationships across chemistry, modality, informatics, automation, and technology organisations. Success will depend on strong technical delivery, sound scientific judgement, and the ability to work effectively and influence colleagues across multiple teams. The role will require full-time on-site presence. Key Responsibilities Mass Spectrometry & Platform Technical Delivery Serve as a hands-on expert in mass spectrometry (LC-MS, HRMS, and related techniques), delivering high-quality analytical data and method development support for small molecule and next-generation modalities, including divalent small molecules, WLPs, and oligonucleotides. Develop, optimise, and troubleshoot mass spectrometry methods to support platform capability, ensuring robust, reproducible, and high-quality data. Contribute technical input into platform modernisation, including evaluation of new mass spectrometry instrumentation, technologies, and workflows. Scientific & Technical Contribution Provide expert analytical input on complex mass spectrometry challenges, supporting method development, troubleshooting, and data interpretation. Apply strong scientific judgement to ensure robustness, reproducibility, and data quality in day-to-day analytical work. Act as a technical resource and point of contact for mass spectrometry-related queries High-Throughput & Workflow Support Support the integration of high-throughput purification and analytical workflows, with particular focus on mass-spectrometry-based analysis, to enable efficient end-to-end support of emerging modality pipelines. Work closely with colleagues in purification, informatics, and automation to ensure smooth operation and continuous improvement of analytical workflows. Contribute ideas to improve platform throughput, data quality, and downstream usability. Collaboration & Communication Work collaboratively with colleagues in Discovery Chemistry, Modality teams, Informatics, Automation, and external collaborators to deliver analytical support aligned with business priorities. Communicate mass spectrometry data, platform capability, and limitations clearly to scientific and functional stakeholders. Support translation of technical findings into clear updates for project-level decision-making. Quality & Continuous Improvement Ensure mass spectrometry and analytical work meets high standards of quality, safety, and compliance, consistent with organisational and regulatory expectations. Contribute to team discussions on prioritisation and risk assessment for analytical platform activities. Drive continuous improvement in mass spectrometry methods and workflows using data-led insight and lessons learned. Basic Qualifications & Skills BSc or equivalent in Chemistry, Analytical Chemistry, Pharmaceutical Sciences, or a related discipline, with several years of postgraduate experience in analytical chemistry and strong hands-on mass spectrometry experience. Demonstrable expertise in mass spectrometry techniques