Senior Director, Applied AI Solutions

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description The Senior Director, Applied AI Solutions, leads the applied AI function within the AI Research Center (ARC), part of Gilead’s Clinical Data Science (CDS) organization in Drug Development. As CDS’s center of excellence for applied AI, this leader is accountable for the technical and product path from a prioritized AI use case defined by CDS functional organizations to a trusted, reusable capability in production — spanning discovery, experimentation, technical validation, first production release, adoption support, and measured value. The ownership model is deliberate. Business ownership of priorities, requirements, funding, process change, and workflow outcomes remains with the CDS and Development functions, including Clinical Data Engineering & Analytics (CDEA) and Statistical Programming. Enterprise platform services, infrastructure, and scaled production operations and support remain with Enterprise IT and Development Systems. This role supplies the AI expertise, solution engineering, and delivery capacity that make both possible, and is measured on how effectively it accelerates outcomes owned by others. The role combines technical depth, product-minded execution, and people leadership. You will define ARC’s applied AI engineering practices — model and prompt lifecycle, evaluation, agent design patterns, solution architecture — and influence the enterprise engineering and architecture standards owned by IT, while remaining close enough to the work to make consequential design decisions and to lead multidisciplinary teams building AI systems for internal CDS and Development users. Priority domains for AI enablement may include clinical data review and insights, study design and operations, biomarker and real-world data workflows, safety and risk detection, regulatory evidence generation, and scientific knowledge access. In each of these domains the owning CDS or Development function leads its own workflow and process transformation agenda; this role provides the AI solutions, methods, and technical expertise that enable it. Applied AI Solutions favors reusable capabilities over isolated proofs of concept. The team builds on Gilead’s approved data, cloud, security, privacy, and responsible-AI foundations and on the enterprise platform services provided by IT, and partners closely with ARC’s Product Management & Experiences (PMx) and AI Acceleration (AIx) functional (scientific and operational) teams, as well as with Development Systems, Enterprise IT, Information Security, Privacy, Legal, Quality, CDEA, Statistical Programming, and business stakeholders. The mandate: turn high-value Clinical Data Science and Development AI problems — as prioritized by their business owners — into trusted, reusable, production-grade AI capabilities that improve how Gilead designs, conducts, analyzes, and learns from clinical development. Key Responsibilities As the Senior Director of Applied AI Solutions, you will: Applied AI engineering roadmap. In partnership with CDS and Development business owners, Enterprise IT, and ARC leadership, translate prioritized AI demand into a multi-year applied AI engineering and delivery plan tied to CDS and Development outcomes. Business owners decide what to pursue and why; you bring the AI expertise that informs those decisions — feasibility, solution options, effort, data readiness, reuse potential, and technical risk — recommend sequencing, and supply the evidence that allows owners and governance forums to decide whether to scale, redesign, or stop an initiative. Anchor on the core, high-value Development AI priorities while also enabling CDS priorities beyond DevAI and IT-funded use cases; for those outside the enterprise-funded portfolio, CDS functional leaders hold business ownership of the roadmap and requirements, and this role builds agents and solutions directly or guides partners to evaluate, select, and integrate the right third-party capabilities. AI solution design and delivery (0→1). Own the design, build, evaluation, and technical validation of AI services, applications, agents, and shared components through first production release. Co-design with Enterprise IT and Development Systems from the outset so that solutions are built for scale, then hand over to IT-owned platform and operations for enterprise scaling and sustained run, remaining the accountable AI technical partner after transition. Establish reference solutions and workflow designs for model gateways, retrieval-augmented generation (RAG), semantic search, knowledge graphs, multimodal AI, tool use, workflow orchestration, human review, and integration with validated enterprise systems. Agentic systems and interoperability. Guide the responsible use of agentic patterns for bounded, auditable CDS workflows. In partnership with Enterprise IT, Information Security, and Privacy, use open interoperability protocols such as MCP and A2A where appropriate to connect AI applications and agents to governed data, tools, and workflows, and ensure authorization, least-privilege access, provenance, action controls, and human escalation are designed in from the start and that agents are registered in the enterprise agent registry. AI engineering excellence. Define and uphold ARC’s applied AI engineering practices — data contracts, model and prompt lifecycle management, evaluation harnesses, LLMOps/MLOps, automated testing, and reproducible releases — while adopting and contributing to the enterprise standards owned by IT for software engineering, infrastructure as code, CI/CD, and security. Build for reliability, latency, cost, maintainability, portability, and graceful failure, not demonstrations alone. Evaluation, observability, and responsible AI. Make evaluation a first-class engineering discipline. Establish offline and online evals, gold-standard datasets, task and outcome metrics, trace-based observability, model and data monitoring, adversarial testing, and incident response. Partner with Responsible AI enterprise teams and control functions to implement risk-tiered governance, privacy, security, records, auditability, explainability, and GxP or regulatory controls when applicable. Adoption and value realization. Co-own product discovery and experience design with PMx and support adoption alongside CDS workflow owners. Operate as an expert partner, not a gatekeeper — augmenting their workflows while they retain ownership of priorities, requirements, process change, and outcomes. Working from baselines the business defines, instrume