HEOR - Director, Methods

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. Organization Overview: At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. HEOR Methods This role provides methodological leadership across the full span of HEOR evidence generation, including comparative effectiveness and pharmacoepidemiologic methods, systematic literature review and meta-analytic techniques (network meta-analysis and indirect treatment comparison), health technology assessment methodology, and cost-effectiveness and economic modeling. The successful candidate will have deep expertise in causal inference methods for observational data (target trial emulation, active-comparator new-user design, marginal structural models), quantitative synthesis methods for building comparative evidence in the absence of head-to-head trials, and the construction and critique of decision-analytic models (Markov, discrete event simulation, budget impact) used to support payer and HTA submissions. This person functions as the internal scientific authority ensuring that evidence generation, from observational study design through economic modeling, meets the rigor required for regulatory engagement, HTA body review, and payer value communication, while partnering closely with biostatistics, epidemiology, global market access, and external academic and consulting collaborators. Candidates should bring a strong publication record spanning comparative effectiveness, meta-analytic, or health economic methods, direct experience building or critiquing cost-effectiveness models and HTA dossiers (NICE, ICER, or comparable bodies), and the judgment to identify where methodological choices in any of these domains create downstream regulatory, payer, or scientific risk. Position Summary: The demand for high-quality health economic and outcomes research (HEOR) and real-world evidence (RWE) to support drug development, health technology assessment/access decisions, product differentiation, and clinical decision making continues to grow. The purpose of the Lilly Health Economic and Outcome Research team is to accelerate equitable patient access and transform healthcare delivery through the execution and communication of bold, high impact science. HEOR provides strategic insight/leadership into the health outcomes (HO) evidence needs (e.g., health economics, patient reported outcomes, real world evidence, access and reimbursement) for Lilly’s portfolio. As an HEOR technical lead within the cardiometabolic health (CMH) business unit, this individual partners to develop the real-world evidence, patient-reported outcome, and economic value strategy across the therapeutic area and leads, manages, and develops a team of HEOR scientists. The scientist will use their knowledge of HO disciplines, therapeutic area knowledge of disease states in the Lilly portfolio, understanding of drug development and commercialization, and geographic market knowledge in the role. Research project ownership and execution is required. The scientist may have duties ranging from developing and articulating product value propositions, patient reported outcomes strategies, real world evidence generation, and differentiation strategies using HO research depending on the individual assignment. Responsibilities: Strategy Drives sustained integration of HEOR from early clinical development through commercialization depending on focus of role. Develops and oversees HO research strategy for compounds in the Lilly portfolio in the relevant therapeutic area(s). Serves as the senior HEOR strategic partner on lead/core teams throughout development and/or commercialization Formulates and drives Patient Focused Outcome (PFO), Real World Evidence, and/or economic value strategies for priority products and geographies. Establishes consistent yet agile HEOR standards across the CMH portfolio, enabling evidence generation to scale as the pipeline evolves. Study Development and Execution Develops bold high impact science for products across the lifecycle, to influence and support evidence needs for Lilly products in support of improving patient outcomes. Applies technical expertise appropriate for the role (e.g., scope or depth in statistical analysis, economic modeling, clinical trials, PFO development, observational/ epidemiologic research, and health technology or other value assessment) within a therapeutic area. Applies disease state knowledge and research methods to solve HO issues associated with registration, pricing, reimbursement, and access initiatives Organizational Leadership and Influence Provide guidance and mentorship to junior scientists and colleagues in HEOR methodologies and best practices. Communicates technical expertise with business acumen in a simple, succinct way. Leads HO evidence planning and implementation in collaboration with cross-functional teams across the development and commercialization lifecycle. Integrates and influences key business partners around HEOR prioritization, trade-offs, and recommendations to achieve strategic goals. Provides consultation, input, and strategic direction about how to leverage HEOR to the enterprise Triages business partners’ requests with excellent prioritization and timeliness. People Leadership and Team Development Leads, manages, coaches, and develops a team of HEOR scientists — setting direction and priorities, managing performance, and building individual capability and career growth. Allocates talent and resources across the CMH portfolio, matching team capacity to the highest-value evidence priorities. Builds an inclusive, high-accountability team culture and models the Team Lilly leadership expectations (Include, Innovate, Accelerate, Deliver). Information Dissemination Effectively communicates HO information to internal business partners, the scientific community, and customers. Drives research dissemination strategies and leads research communication efforts including abstracts, posters, podium presentations, promotional materials, and manuscripts. Plan for, align, and drive application of results/deliverables to increase the impact of HO work Environmental Awareness Maintains awareness of significant developments in disease states in the Lilly portfolio and HO field including current HO methodologies and application