Manager, Business Systems

Guardant Health Palo Alto, CA Updated 24 September 2026
PharmaBiotechRegulatory AffairsQuality Assuranceedcemacroinform

Job description

Company Description Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant® is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn , X (Twitter) and Facebook . Position Summary: The Manager, Business Systems is a hands-on leadership role responsible for managing and optimizing Oracle ERP Cloud applications across Record to Report (R2R), Procure to Pay (P2P), Order to Cash (O2C), ARCS, RMCS, Billing, and Revenue Management processes. This role combines functional and technical expertise with strong leadership skills to support daily ERP operations, system enhancements, Projects, integrations, and strategic initiatives. The Manager will lead ERP support resources and partner closely with Finance and Operations stakeholders to deliver scalable, reliable, and compliant business solutions. The ideal candidate will possess strong analytical, problem-solving, and communication skills, with the ability to work cross-functionally and drive continuous improvement across enterprise systems and business processes. Essential Duties and Responsibilities: Lead analysis, design, implementation, and support of the Oracle Fusion Financial Cloud production environment for the Record to Report, Order to Cash, and Procure to Pay track (GL, AR, AP, FA, CM, SLA, PO, OM, Fusion Tax). Define team structure, roles, and responsibilities to ensure effective coverage across ERP functional areas (R2R, P2P, O2C). Manage resource planning, capacity, and workload distribution to meet business priorities and SLAs. Coordinate with end-users and other stakeholders to ensure timely and accurate performance of the production environment supporting Finance and Operations, and support Month-End, Quarter-end, and Year-end Close. Take ownership of setting up and configuring the Oracle Fusion Cloud application, and participate in testing during system upgrades, Projects, and enhancements. Lead and manage a team of ERP analysts and support resources, including offshore teams, ensuring high-quality delivery and continuous development. Own prioritization and governance of ERP enhancements, balancing business needs, risk, and system performance. Act as the primary point of contact for Finance and Operations leadership for all ERP-related initiatives, escalations, and strategic discussions Work closely with the integration team to design, troubleshoot, and resolve data-related issues in daily operations. Suggest & maintain monitoring reports. Creates, analyzes, and executes complex reports, queries, and data using BI Publisher/OTBI to support the various reporting requirements of Finance and Operations. Manage backlog of user requests, with regular status reporting of prioritization of new items, WIP, and completed items. Stay current with vendor upgrades, new functionality, and feature releases, and assess adoption strategies. Lead organizational change management efforts related to ERP enhancements, including communication, training, and user adoption strategies. Understand Guardant Health’s business models and work closely with end-users to identify, recommend, and implement business process improvements. Perform as a core team member and/or participate in ERP project initiatives. Document systems procedures to facilitate cross-training. Qualifications: Bachelor's degree with 12+ years of experience with a concentration in Computer Science, Information Technology, information systems, or a related field (required) Strong hands-on functional experience with Oracle Fusion Cloud Financials. Hands-on experience supporting a live Oracle Fusion Cloud production environment, including troubleshooting functional issues, configurations, enhancements, and ongoing production support. Experience gathering business requirements, designing solutions, configuring Oracle Fusion, leading testing/UAT, and supporting deployments Strong Finance and Accounting process knowledge with the ability to work directly with Finance stakeholders and translate business requirements into Oracle solutions. Experience leading ERP analysts/ support resources and working with offshore teams/vendors while remaining hands-on when needed. Strong communication, stakeholder management, problem-solving, and interpersonal skills. Preferred Experience: Experience with RMCS, ARCS, Advanced Collections, Revenue Recognition/Billing, Fusion Tax, Procurement/PO, and Order Management/OM. Experience with Oracle reporting tools such as OTBI, BI Publisher, FRS, and SmartView. Experience with Oracle integrations and middleware platforms such as MuleSoft or similar technologies. Oracle Fusion Cloud Financials certifications. Experience with Oracle EPM, including EPBCS/FCCS and EDM. SOX, audit, application security, and access-control experience Healthcare or life sciences industry experience. AI & Digital Fluency Demonstrate curiosity, sound judgment, and the ability to critically evaluate and responsibly leverage AI-enabled tools in accordance with company policies, ethical standards, and regulatory requirements to improve the efficiency, effectiveness, and quality of work. Hybrid Work Model: This section is applicable to onsite employees who are eligible for hybrid work location as specified by

Stand out for this role

NoxPharm tailors your CV to this job description by aligning your experience with the role requirements and terminology. Built for pharma & life sciences.

Tailor my CV now — free to try