VP, Disease Business Unit General Manager, US

Job Description Vertex is seeking a seasoned commercial executive to serve as VP U.S. General Manager (GM), accountable for end-to-end business performance, including results delivery, performance management, budget and strategic priorities for their designated portfolio, in the US. The VP GM will lead a fully integrated U.S. Business Unit, with responsibility for commercial execution through cross-functional alignment to sustain market leadership while preparing for future innovation. Key Duties & Responsibilities Owns full P&L responsibility for the U.S. designated Business Unit, delivering against revenue, profitability, and long-range plan commitments Leads an established commercial organization with opportunities for future builds with direct reports across Sales and Marketing Drives cross-functional leadership and decision-making across Market Access, Patient Services, Analytics, Commercial Operations, Medical Affairs, R&D, Manufacturing, Legal, Regulatory, Government Affairs, and Patient Advocacy Ensures continued excellence in launch execution for future indication expansions, and lifecycle management Develops and maintains a high-performing leadership bench with strong succession planning Serves as enterprise steward of Vertex’s designated therapeutic area franchise in the U.S., balancing near-term performance with long-term sustainability Leads the organization through the dynamics of a highly penetrated, mature market Partners with Medical Affairs and Patient Services to ensure patient-centric engagement models reflecting lifelong treatment journeys Maintains trusted relationships with the Disease communities including advocacy organizations and treatment centers Owns the U.S. revenue forecast, expense management, and resource allocation, in collaboration with the Business Unit Leadership. Champions a culture of operational rigor, continuous improvement, and ethical leadership, ensuring full compliance with all company policies and regulatory standards Required Experience Typically requires 15+ years of pharmaceutical or biotech experience, with deep commercial leadership exposure Minimum of 8–10 years of senior people leadership experience, including responsibility for large, matrixed organizations Demonstrated success leading large, in‑market franchises with sustained performance over time Preferred experience includes: Portfolio and lifecycle management Operating effectively within highly visible, enterprise‑critical franchises Experience engaging externally with advocacy groups, policymakers, and senior healthcare stakeholders Required Knowledge / Skills Proven enterprise‑level commercial leadership with strong strategic, financial, and operational acumen Ability to lead through scale and complexity, balancing performance delivery with long‑term franchise stewardship Exceptional executive communication skills, with the ability to influence the EC, Board, and external stakeholder levels Strong track record of building leaders, not just teams, and developing future general managers Deep experience operating in cross‑functional, highly regulated environments Demonstrated ability to manage significant budgets and complex trade‑offs Uncompromising commitment to ethics, compliance, and Vertex’s values and reputation At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $368,000 - $552,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify E