Principal Scientist / Senior Principal Scientist - Peptide Synthesis

Let’s build the future of medicine—together. Genome Valley, Hyderabad, India | Full-Time YOUR ROLE As Senior Principal Scientist / Principal Scientist, Peptide Synthesis at Enveda, you will build and lead our peptide synthesis group from the ground up. You will set up the lab, define synthesis, purification and QC standards, and grow a team of 3-4 chemists who turn sequences designed by our project teams into high-purity, well-characterised peptides for therapeutic programmes. The role starts hands-on at the bench and moves toward leadership as the team matures. WHAT YOU'LL DO Synthesise linear, cyclic, lipidated and modified peptides by Fmoc SPPS (manual, microwave and automated), including orthogonal on-resin chemistry for branching and cyclisation Troubleshoot difficult sequences (aggregation, racemisation, aspartimide formation) and give the design team early feedback on synthetic feasibility Guide preparative RP-HPLC purification, interpret HPLC and LC-MS data, and decide between re-purification, re-synthesis and release Set up the lab: specify and qualify synthesisers and lyophilisers, write SOPs, and partner with CROs/CDMOs for scale-up Hire, train and mentor 3-4 chemists; plan workloads, run technical reviews and build a strong safety culture WHAT WE'RE LOOKING FOR PhD in organic or peptide chemistry with 10-12 years of hands-on peptide synthesis experience, including 2-3+ years leading or mentoring a team Deep Fmoc SPPS expertise (manual, automated and microwave) with demonstrated success on long, hydrophobic, cyclic, multi-disulfide and lipidated peptides Strong LC-MS interpretation skills and experience scaling from mg to hundreds of mg or gram scale GLP-1-type or macrocyclic peptide experience, or experience setting up a peptide lab, is a strong plus Clear communicator who can explain the limits of peptide chemistry to non-chemists We hire for trajectory, not just credentials. If you meet most of the above and care deeply about this problem, we want to hear from you. ABOUT ENVEDA We're a clinical-stage, AI-enabled biotech discovering medicines four times faster than the industry standard. We recently raised $150M in a Series D, reached unicorn status, and advanced our first drug into Phase 2 trials. Forbes named us one of America's Best Startup Employers. Newsweek recognized us as a Top 100 Most Loved Workplace. We're building something rare — and we're just getting started!