Director, Performance & Digital Marketing

Company Description Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant® is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn , X (Twitter) and Facebook . The Senior Director, Performance & Digital Marketing will set strategy and lead execution for all paid media, advertising, and digital marketing across Guardant Health’s screening division, including for: Consumer, Healthcare Provider (HCP), and Health Systems audiences. A central responsibility of this role is leadership of Shield’s significant multi-million-dollar national direct-to-consumer (DTC) media investment across television, streaming, digital video, search, social, programmatic, CRM, and emerging channels. This leader will be accountable for ensuring that the investment builds the Shield brand, increases consumer demand, drives measurable action, and contributes to commercial growth. Beyond DTC, the Senior Director will oversee the integrated media and digital ecosystem for HCP and Health Systems audiences, including professional media, account-based marketing, web, CRM, marketing automation, organic social, and conversion optimization. As a senior member of the Screening Marketing leadership team, this individual will establish portfolio-wide investment priorities, performance standards, agency models, measurement frameworks, and digital capabilities. The role requires strong commercial judgment, financial discipline, cross-functional collaboration, executive influence, and the ability to translate a significant marketing investment into measurable business impact. The ideal candidate is an accomplished performance and digital marketing leader who combines strategic vision, analytical rigor, and organizational leadership. They must be able to influence senior stakeholders, challenge agency and internal thinking, make disciplined investment decisions, and build a high-performing team in a fast-moving, highly regulated environment. Key Responsibilities DTC Media Investment and Growth Leadership Own the strategy, deployment, optimization, and performance of Shield’s significant multi-million-dollar DTC media investment, one of the most important growth investments within the Shield business. Set the national consumer media strategy across television, streaming, online video, search, social, programmatic, audio, local media, and emerging channels. Determine investment levels, channel allocation, audience strategy, geographic prioritization, flighting, reach, frequency, and optimization approaches. Balance long-term brand building with near-term demand generation and measurable patient action. Partner with Consumer Marketing leadership to translate brand and audience strategy into an integrated media plan that builds awareness, creates urgency, and motivates patients to ask for Shield by name. Advise the Vice President of Marketing and senior commercial leadership on major investment decisions, trade-offs, risks, and opportunities. Lead executive-level reviews of DTC performance, clearly articulating what is working, what is not, and where investment should be increased, redirected, or reduced. Ensure rigorous budget stewardship, including forecasting, pacing, agency fees, production implications, working versus non-working spend, and financial reconciliation. Build a measurement framework that connects DTC investment to awareness, consideration, site engagement, patient action, provider demand, test orders, and incremental business impact. Establish a disciplined testing agenda across audiences, creative, messaging, channels, media weight, sequencing, and geographic markets. Enterprise Media and Advertising Leadership Set the portfolio-wide advertising and paid media strategy from Screening across Consumer, HCP, and Health Systems audiences. Establish an integrated media architecture across national consumer advertising, HCP professional media, Health Systems and account-based marketing, local market activation, and emerging channels. Partner with Consumer, HCP, and Health Systems Marketing leaders to translate audience strategies and business priorities into cohesive, differentiated media plans. Ensure that DTC, HCP, and Health Systems media strategies reinforce one another while addressing the distinct needs of patients, providers, and healthcare organizations. Serve as the senior internal authority on media strategy, investment effectiveness, agency performance, and optimization. Lead media agency strategy, scope, selection, governance, and performance management, holding partners accountable for strategic quality, innovation, operational excellence, transparency, and measurable business impact. Monitor competitive activity, category dynamics, media consumption trends, and regulatory developments to protect and extend Shield’s leadership position. Performance and Measurement Define the performance framework for Shield’s media and digital investments, including business objectives, KPIs, benchmarks, testing plans, attribution approaches, and optimization standards. Partner with Analytics and Finance to connect media performance to patient demand, provider engagement, account adoption, test orders, screening completion, and other commercial outcomes. Advance incrementality, attribution, marketing-mix, and audience-quality measurement as Shield’s data maturity evolves. Lead quarterly and annual performance reviews, identifying where to accelerate, redirect, or reduce investment. Ensure senior leaders have a clear, decision-oriented view of performance, risks, opportunities, and recommended actions. Digital Marketing Set the enterprise digital marketing strategy for Shield across Consumer, HCP, and Health Systems audiences. Direct the evolution of Shield’s web ecosystem to improve awareness, education, engagement, conversion, and customer experience