Senior Manager, IT Operations

Senior Manager, IT Operations ABOUT PACIFIC BIOSCIENCES Pacific Biosciences (PacBio) designs, develops, and manufactures advanced sequencing solutions that help scientists resolve genetically complex problems in human biomedical research, plant and animal sciences, and beyond. Our HiFi long-read and short-read platforms are used across research institutions, clinical labs, and commercial organizations worldwide. Delivering on that mission depends on an IT organization that keeps R&D, manufacturing, quality, commercial, and G&A teams productive, secure, and audit ready. POSITION SUMMARY We are seeking a hands-on Senior IT Manager to own the operational core of PacBio's IT function. This role is accountable for end-user support and help desk operations, core infrastructure (network, compute, data center, cloud), vendor and contract management, IT change management, project and portfolio management, hardware and software asset inventory, software license management, and IT communications to the business. This is a builder-operator role. You will lead and grow a small support and infrastructure team while simultaneously standardizing how IT plans, prioritizes, changes, and communicates its work. Success looks like measurably faster ticket resolution, a stable and well-documented infrastructure footprint, disciplined change control that holds up under audit, an accurate asset and license position that drives real cost savings, and a business that always knows what IT is doing and why. The role partners closely with Information Security, Facilities, Quality/Regulatory, R&D, Manufacturing Operations, and Finance, and operates in a regulated environment where systems supporting GxP and ISO-governed processes require validated, documented, and traceable change. KEY RESPONSIBILITIES Help Desk & End-User Services Own day-to-day help desk operations across all sites: intake, triage, prioritization, escalation, and resolution of end-user incidents and service requests. Define and manage service levels (SLAs/OLAs), queue health, and on-call and escalation coverage; publish and act on metrics for first-contact resolution, mean time to resolve, backlog age, reopen rate, and customer satisfaction. Directly manage, coach, and develop help desk and end-user support staff; set performance expectations, run 1:1s, and build career paths and cross-training coverage. Standardize endpoint provisioning, imaging, MDM, onboarding and offboarding, and lab-adjacent workstation support in coordination with Security and HR. Drive down ticket volume at the source through root-cause analysis, self-service knowledge base content, and automation of repetitive requests. Infrastructure & Operations Own the reliability, capacity, performance, and lifecycle of core infrastructure: LAN/WLAN/WAN, firewalls, server and storage estate, on-premises data center and lab network environments, virtualization, backup, and hybrid cloud services. Lead infrastructure roadmap and refresh planning, including hardware end-of-life, firmware and patch cadence, and capacity forecasting tied to headcount, instrument, and manufacturing growth. Own IT business continuity and disaster recovery: define RTO/RPO with business owners, maintain backup and recovery design, and run periodic restore and failover testing. Support site, lab, and facility buildouts and relocations - network deployment, structured cabling coordination, data center and lab connectivity, and end-user readiness - with minimal disruption to research and production. Partner with Information Security on hardening, vulnerability remediation, access control, monitoring, and incident response; ensure infrastructure controls are documented and evidence-ready. Vendor Management Own the IT vendor portfolio end to end: sourcing, technical evaluation, RFP/RFQ, selection, onboarding, and ongoing performance management across hardware, software, managed service providers, telecom, and professional services. Negotiate and manage contracts, SOWs, renewals, and MSAs in partnership with Procurement, Legal, and Finance; track renewal calendars so no agreement auto-renews unexamined. Run structured vendor business reviews against defined SLAs, deliverables, and spend; escalate and remediate underperformance. Identify and deliver cost savings and cost avoidance through consolidation of redundant platforms, right-sizing, competitive bidding, and rationalization of overlapping tools. Own IT operating and capital budget inputs: forecasting, purchase requisitions, accruals, variance explanation, and spend reporting. Change Management Own the IT change management process: change intake, risk classification, impact assessment, technical and business approval, scheduled change windows, and post-implementation review. Chair the Change Advisory Board (CAB) and maintain the forward schedule of change; enforce standards for rollback plans, testing evidence, and communication requirements. Ensure changes to systems supporting GxP, ISO 13485/9001, and other regulated processes are executed with the documentation, validation, and traceability required to withstand internal and external audit. Lead incident and problem management for infrastructure and service outages, including root-cause analysis and corrective and preventive actions that feed back into the change process. Drive organizational change adoption - training, rollout communications, and support readiness - for new tools and platform migrations. Project & Portfolio Management Own the IT project portfolio: intake, business case and prioritization, resourcing, sequencing, dependency management, and executive-level status reporting. Establish and run standard operating mechanisms - quarterly roadmap planning, stage-gate reviews, risk and issue registers, and portfolio dashboards - so leadership has consistent visibility into scope, schedule, budget, and risk. Personally lead or oversee delivery of high-impact infrastructure and service programs from initiation through closure and operational handover. Track portfolio-level metrics (on-time delivery, budget variance, resource utilization, benefit realization) and use them to rebalance priorities. Build and maintain reporting tooling and dashboards that reduce manual reporting effort and improve decision quality. System & Software Inventory (IT Asset Management) Own the IT asset management program and the accuracy of the CMDB and asset repository across endpoints, servers, network gear, lab-attached IT systems, mobile devices, and software. Define and enforce asset lifecycle process: procurement, receipt, tagging, assignment, transfer, refresh, secure decommissioning, and certified data destruction and e-waste disposal. Establish automated discovery and reconciliation so the inventory of record reflects reality, and run periodic physical audits to validate it. Maintain the authoritative application inventory - owner, business criticality, data classification, integrations, hosting model, regulatory scope, and support status - as the foundation for security, disaster recovery, and audit response. Provide asset and configuration data on demand to Security, Quality, Finance, and audit stakeholders. License Management Own software license and SaaS subscription management: entitlement tracking, true-up readiness, compliance posture, and audit defense across major publishers. Reconcile entitlements against deployed and actual usage; reclaim idle or underus