Distinguished Scientist, Transgenic Model and Technology

Job title: Senior Distinguished Scientist for Transgenic Model and Technology Location: Cambridge, MA About the job The Translational In Vivo Models (TIM) department within Sanofi's R&D is seeking an exceptional Senior Distinguished Scientist to lead our Transgenic Model & Technology (TMT) function globally. This strategic leadership role will drive innovation in genome engineering and genetically modified model development to accelerate drug discovery across all therapeutic divisions. As the G lobal Head of Transgenic Biology , you will ensure our organization remains at the forefront of technical developments in genome engineering, enabling breakthrough discoveries in immunology, immuno-inflammation, rare diseases, neuroscience, and oncology. You will serve as a key scientific advisor and strategic thinker, shaping the direction of in vivo and preclinical research programs while championing the integration of emerging technologies — including AI and digital platforms — into transgenic science. This role is based in Cambridge, MA and is primarily office/lab-based with some scope for flexible remote working. Key Responsibilities Scientific Leadership & Innovation • Lead and advance state-of-the-art genome engineering techniques and mouse genetics applications for in vivo model development supporting discovery and developmental research • Apply personal expertise in transgenesis and CRISPR technology to devise and execute sophisticated experimental strategies for target validation, proof-of-concept, and efficacy studies • Identify, evaluate, and implement new technologies and innovations in transgenesis, CRISPR/Cas systems, and emerging genome engineering platforms • Serve as a strategic thinker and scientific advisor to research projects across therapeutic areas, providing expert guidance on in vivo and preclinical study design • Champion the integration of AI and digital technologies to enhance model design, data analysis, and predictive capabilities in transgenic research • Cover a broad scientific scope including immunology and immuno-inflammation, rare diseases, neuroscience, molecular and immune-oncology, and all areas of cell and molecular biology pertaining to immunology and immune-oncology Strategic Planning & Cross-Functional Leadership • Demonstrate strategic thinking and orientation in aligning transgenic capabilities with organizational research priorities and long-term scientific goals • Lead and coordinate transversal teams and projects across multiple therapeutic divisions, sites, and external partners • Collaborate closely with the Head of Transgenic Division, drug discovery program leaders, cluster heads, and department heads to provide strategic scientific advice • Drive budget planning, forecasting, and financial management to optimize resource allocation and operational efficiency Operational Excellence & Partnership Management • Establish and maintain comprehensive project management frameworks ensuring full-service delivery from model design through study-ready animal production • Build and manage strategic relationships with model providers, CROs, and academic partners for development and delivery of genetically modified models • Negotiate and oversee license agreements and partnership contracts for model acquisition and technology access • Implement quality standards and continuous improvement initiatives to maintain operational excellence People Leadership & Development • Supervise, mentor, and develop staff members to build a high-performing team at the forefront of transgenic science • Participate in talent management decisions including hiring, promotions, performance evaluations, and organizational development • Foster a culture of scientific excellence, innovation, collaboration, and continuous learning Minimum Education and Experience Required • Ph.D. in Molecular Biology, Genetics, Developmental Biology, or a related discipline • Extensive post-doctoral or industry experience in mouse molecular genetics and transgenic animal model development • Demonstrated track record of scientific leadership in an academic or pharmaceutical/biotech research environment • Minimum of 5 years of demonstrated, hands-on experience performing this role. Additional Qualifications Technical Expertise • Deep expertise in developing transgenic animal models, including engineering diverse genetic alleles using CRISPR/Cas9, Cas12, base editors, prime editors , and other advanced genome engineering systems • Comprehensive knowledge of both theoretical principles and practical methodologies required to lead a state-of-the-art transgenic facility • Strong foundation in molecular biology, mouse genetics, embryology, and reproductive technologies • Experience across multiple therapeutic areas (immunology, oncology, rare diseases, neuroscience preferred) Leadership & Strategic Capabilities • Proven strategic thinking and orientation with ability to align scientific capabilities with business objectives • Demonstrated success leading transversal teams and managing complex, multi-stakeholder projects across sites and functions • Established track record as a scientific thinker and advisor to in vivo and preclinical research programs • Experience identifying, evaluating, and implementing new technologies and innovations in a research setting • Familiarity with and application of AI and digital technologies in biological research, model design, and data analysis Professional Skills • Exceptional project management skills with ability to oversee multiple concurrent initiatives • Strong contract negotiation and vendor management capabilities • Excellent budget planning, financial management, and resource allocation skills • Outstanding interpersonal and communication skills (written and verbal) for effective collaboration across diverse, global stakeholders • Proven ability to work in matrix organizations and influence without direct authority Personal Attributes • Self-motivated with demonstrated ability to lead and thrive in collaborative team environments • Comfortable managing competing priorities and adapting to dynamic research needs • Commitment to scientific excellence, integrity, and ethical research practices • Passion for mentoring and developing scientific talent • Candidates must be willing to travel as part of this position. What We Offer • Opportunity to shape the future of transgenic technology at a global biopharmaceutical leader • Access to cutting-edge technologies and resources across a world-class R&D organization • Collaborative, innovative research environment spanning multiple therapeutic areas • Competitive compensation and comprehensive benefits package • Professional development and career growth opportunities • Flexible work arrangements supporting work-life balance Why Choose Us? Bring the miracles of science to life alongside a supportive, future-focused team. Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally. Enjoy a thoughtful, well-crafted rewards package that recognizes you