Senior Scientist (12-Month Fixed Term Contract), Oncology Research

Senior Scientist ( 12-Month Fixed Term Contract ) , Oncology Research Location: Cambridge (Discovery Centre) Introduction to the Role: At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We’re passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life. Are you ready to work on one of the most exciting Oncology pipelines in industry? About the Role: AstraZeneca’s vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. We are seeking a highly motivated Senior Scientist with deep scientific and technical expertise spanning both adaptive and innate immune cell biology with a track record of scientific excellence to join Immune Cell Engagers Discovery team in Cambridge, UK for a 12-month period . As a Senior Scientist , you will be a key member of a team focused on supporting immune-oncology projects through the drug discovery process. You will bring your theoretical and practical expertise in immunology to establish assay systems and deliver datasets that will have direct impact on immune-oncology research projects. Main Duties and Responsibilities Working in this laboratory-based position within the Immun e Cell Engagers D iscovery group , you will develop, design, conduct and analyse in - vitro and/or ex - vivo experiments to assess the function of our candidate drugs and help us to dissect the mechanism of action of novel therapeutics targeting the immune system for cancer therapy. You will also review emerging literature and internal data to help in identifying new potential targets and contribute to target validation activities. A strong foundation in immunology / immuno-oncology, and an in- depth technical expertise for the analysis of immune function and phenotype is essential for this role. As a highly organised and self-motivated individual with a strong lab/practical background, you will stay up to date with relevant technical and intellectual scientific expertise in tumour immunology and have a genuine passion for this field of research! Essential Requirements A PhD, or equivalent experience, in immunology /I mmuno-oncology / cancer biology . Extensive background in immunology and/or immun o - oncology . Experience of a range of in - vitro and ex - vivo technical skills for the analysis of human immune cell function s via multiparameter flow cytometry, ELISA /multiplex assays , ELISPOT, primary immune cell isolation and co-cultures, cell killing assays ( like TDCC, ADCC, CDC , ADCP ) , TIL s isolation and phenotyping. M olecular biology skills including gene expression analysis and stable cell line generation. Working e xperience with immune cell assays and/or characterization is highly desirable. Strong interpersonal, influencing, negotiating and collaboration skills together with evidence of having used these skills to support problem solving and in deliver ing the projects in a collaborative environment. Depth of understanding and strong enthusiasm for immunology and immuno-oncology . Proven track record of scientific accomplishments , as evident from publication s/patents. Data processing, statistical analysis,</spa