Spring Co-Op 2027, In Silico Modeling

Job Description Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects: You’ll work on assignments that make a real impact, not just busy work. Mentorship & Networking: Connect with leaders and peers who want to see you succeed through professional networks, connections, and collaborations that will shape your longer-term career. Flexible & Supportive: We offer flexible work options with Flex @ Vertex and prioritize your wellbeing. Inclusive Culture: Collaboration and inclusion are embedded in everything we do. Career Launchpad: Build skills, explore career paths, and get guidance for your future career. Your Impact The Vertex In Silico Modeling Co-Op is a 6-month experiential training program for students currently working towards an advanced degree in Computational Chemistry, Computational Biology or other related fields. If you are passionate, collaborative, and growth-minded, a co-op at Vertex will help you gain meaningful experience in our Analytical Development functional areas and serve as a launchpad for your career. The application deadline for this co-op is November 15th. Please note that Vertex reviews applications on a rolling basis and reserves the right to close this job posting prior to the listed deadline. Applicants can expect to receive an update about their application before or shortly after the application deadline. Ready to apply? Submit your application and let’s turn possibilities into reality! What you will be doing: We are seeking a highly motivated Co-Op to join our group, focusing on developing in silico modeling tools to understand structure function relationship for biologics therapeutics. As a Co-Op at Vertex Pharmaceuticals, you will have the unique opportunity to gain practical experience and contribute to meaningful projects. This co-op role is designed to provide you with exposure to various aspects of therapeutics development, helping you build valuable skills while working alongside experienced professionals in a dynamic and innovative biopharmaceutical environment. Key Responsibilities: Build workflows for protein structure prediction and contribute on protein structure-function relationship understanding Utilize molecular dynamics simulation tools to evaluate protein-protein and protein-excipient interactions, predict macroscopic properties such as aggregation propensity, protein solution viscosity, and Leverage experimental data to further refine the model and workflows Evaluate Vertex pipeline molecules with established workflows as needed Report on project progress, write analytical development protocols and method development reports. Maintain excellent written documentation (e.g. lab notebook and test forms) Qualifications: Ph.D. candidate or highly experienced Master's student studying, Computational Sciences, Biology, Chemistry or a related field Hands-on experience with in silico modeling and structural prediction of proteins and antibodies Hands-on experience with molecular dynamics simulation and understanding of protein-ligand and protein-protein interaction Ability to adapt and be flexible with respect to working schedule Excellent communication skills with the proven ability to build open and collaborative relationships and work effectively as a member of a multidisciplinary team Familiar with modeling tools such as: MOE, Maestro/Schrodinger, Desmond, GROMACS, NAMD/VMD Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships/co-ops or entry level roles within this part of the organization. You must be enrolled in an advanced degree program if graduating before May 2027 You must be available to work full-time, 40 hours per week from January – July 2027 Program Details: Full-time, paid co-op $33.00 – 50.00 USD/hour Program Dates: January – July 2027 Application Deadline: November 15th, 2026 At Vertex, we believe that when you feel your best, you can perform at your best. That’s why our US benefits and global well-being resources are designed to support you. • Free 24/7 onsite gym access and free access to group exercise classes • Subsidized commuter benefits- transit and parking • Provided meals—free breakfast daily! • Career development opportunities and events, including C Suite engagement • Social events—both intern-only and company-wide • Location-specific perks and extras! • Recognition of National Intern Day Our Ways of Working Flex Designation: On-Site - Boston Flex Eligibility Status: On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. This job posting is for a temporary role with a third-party agency partner that provides services to Vertex. The individual selected for this role will be offered the role as an employee of that third-party agency; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency upon offer. At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other jo