Mixed Modality (Peptide Downstream) Scientist - Process Translation and Execution

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. Overview: At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader, headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Organization and Position Overview Lilly recently announced a $4.5 billion investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development, Lebanon, Indiana. The first-ever facility of its kind, combining research and manufacturing in a single location, the Medicine Foundry will allow Lilly to further develop innovative solutions to optimize manufacturing processes and increase capacity for clinical trial medicines, while also reducing costs and environmental impact. The Process Translation and Execution (PTE) team translates API/DS process knowledge into clinical supply readiness, oversees technology transfer, implements phase-appropriate control strategies, and ensures right-first-time clinical manufacturing for a variety of modalities, including synthetic molecules, biologics, peptides, oligonucleotide, and bioconjugates (ADC, ARC, etc.) Through cross-functional collaboration, PTE influences process design, revolutionizes clinical manufacturing, builds capabilities in emerging technologies and aligns with corporate and Lilly Research Labs (LRL) goals, drives scientific excellence and innovation to accelerate manufacturing advancements and propels the site toward long-term business success. In the Foundry Construction and Project Delivery/Startup Phase (2025 to 2028), roles will be fluid and dynamic as we build a new organization, design and implement the necessary systems and business processes required to enable operational readiness, support the project delivery, and build the site culture. Success will require significant collaboration, creativity, and resilience as the Lilly Medicine Foundry transitions from design to startup and ultimately to steady-state operations and continuous improvement. This period presents a unique opportunity for learning, growth, and making a lasting impact. We are seeking passionate and agile chemists to join the PTE team and help bring the Lilly Medicine Foundry’s vision to life. Responsibilities In this role, the Mixed Modality (Peptide Downstream) Scientist will be responsible with evaluating and facilitating the transfer of peptide downstream manufacturing processes, under appropriate supervisory guidance, from development laboratories to pilot plant operations (including kilo-scale and isolator production environments). This enables the successful transition to early-phase cGMP manufacturing of grams to kilogram quantities of API required for clinical trial supply. Perform peptide purification and isolation and assess purification methods from early phase process research and development labs Familiarity with performing peptide downstream procedures, such as reverse-phase chromatography, TFF, lyophilization, and precipitation & drying. Evaluate the safety of the incoming procedures in collaboration with the safety group and process engineering. Ordering and staging chemicals. Obtain reference materials and participate in setting up analytical methods. Reprocess and analyze analytical data to make fact-based decisions. Efficient with summarizing and presenting chemistry and challenges. Perform familiarization executions to ensure plant readiness of process steps including chemical reactions, purification, TFF, lyophilization, and precipitation & drying at the Lilly Medicine Foundry. Perform use-tests of key in-process materials and document Definitive Lab Trials of processes to confirm plant readiness. Maintain a well-organized and detailed lab notebook with accurate descriptions of the procedures, observations, and organized analytical data to enable the preparation of technical packages/technical transfers and accurate replication in receiving labs. Documentation: Author, review technical documents, including tech transfer plan, standard operating procedures (SOPs), batch records, campaign summary reports, and deviation reports. Process improvement: Apply scientific knowledge to identify areas for improvement and implement new technologies or procedures. Contribute to process troubleshooting and investigations by supporting process deviations, quality events, and non-conformances. Collaborate with teams to perform root cause analysis (RCA) and develop effective corrective and preventive actions (CAPAs) Basic Requirements: B.S. or M.S. in chemistry, chemical engineering, or related field. 3+ years of experience in synthesis peptide purification and/or manufacturing environments involving synthetic peptide API or drug substance. Reverse-phase chromatograph is preferred. Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1 Additional Preferences: Working knowledge of peptide downstream chemistry and purification and application towards improvement and optimization. Experience with peptide purification techniques used for developing and scaling-up chemical reactions. Experience using process chemistry concepts is a plus. Proficiency with peptide purification via chromatography and TFF and downstream conjugation and cyclization. Comfortable working with larger sized preparative columns, TFF, and related-equipment. Highly motivated, able to learn rapidly, and demonstrates strong attention to detail. Has experience creating batch records and conducting scale-up experiments according to those records. Ability to prioritize multiple activities and manage ambiguity. Experience with a variety of analytical techniques: HPLC/UPLC, LC-MS, GC, NMR, etc. Process quantification and acquiring mass balance for products and by-products. Demonstrated ability to drive projects and accept change. Communication skills: Excellent written and verbal communication skills for technical report writing, prese