Director, Patient Centered Science, Late CVRM

The Patient Centered Science (PCS) Director leads therapy area and project-level patient- centered evidence strategies , with a focus on clinical outcome assessments (COAs) , patient-reported outcomes (PROs) , and broader patient experience data across the product lifecycle. The role ensures that patient- centered evidence is fit for purpose and supports regulatory approval , HTA/reimbursement needs , and commercialization . The role holder partners with cross-functional teams to define the most appropriate COA/PRO endpoints , identify evidence gaps, and recommend or develop instruments and methods that capture the patient experience and meet stakeholder expectations. They provide strategic leadership from early development through late-stage programs, ensuring that patient- centered evidence is integrated into clinical plans , TPPs/ TPCs , regulatory discussions , and submission dossiers . The PCS Director is accountable for leading patient input activities , including interviews and related evidence-generation approaches, and for translating those insights into scientifically robust recommendations. The role also represents PCS in interactions with regulatory authorities , HTA bodies , external experts, and internal governance teams, while supporting payer evidence needs such as utility and patient preference measurement . In addition, the PCS Director drives consistent TA-level standards for PRO/COA strategy, oversees relevant vendors and subprojects, contributes to scientific communications and publications, and strengthens AstraZeneca’s external reputation in patient- centered measurement science . Key Responsibilities Lead PCS strategy for assigned therapy area(s) and projects, covering COA , PRO , and patient experience evidence needs across development. Advise teams on endpoint strategy , including selection , development, validation, and implementation of fit-for-purpose instruments. Identify evidence gaps and define plans to generate robust patient- centered evidence for regulatory, payer, and clinical decision-making. Provide input to clinical development plans , TPPs/ TPCs , protocols, briefing books, and regulatory submission packages. Lead PCS regulatory and HTA interactions related to PRO/COA evidence and support market access evidence needs where relevant. Generate patient insight through interviews and other research approaches to inform strategy and documentation. Partner cross-functionally with R&D, Medical, Payer, Regulatory, and external experts to align evidence plans and messaging. Manage external vendors and subprojects , including scope, budget, timelines, quality, and deliverables. Drive scientific communication , including presentations, publications, and external engagement to advance AZ’s leadership in PCS. Minimum Requirements Bachelor’s degree in a clinical , biological, social science, or related field. Master’s degree in outcomes research, epidemiology, health services research, health policy, or a related discipline. Doctoral degree MD preferred . At least 5 years’ experience in the biopharmaceutical industry. Demonstrated experience in COA/PRO or broader patient- centered science . Strong understanding of clinical development , study design , and evidence interpretation . Knowledge of qualitative and quantitative methods relevant to patient insight and outcome measurement. Experience working across functions and with external vendors/agencies . Skills and Capabilities Deep expertise in PRO/COA strategy and its application in pharmaceutical development. </