Senior Director, Business Operations Lead – Small Molecule, Commercial Manufacturing and Technical Operations

Job Description General Summary: The Senior Director, Business Operations Lead is a senior role within the Business Operations function supporting Commercial Manufacturing and Technical Operations (CMTO). Reporting to the Executive Director, Business Operations and Performance , this role is accountable for product-level business leadership across commercial manufacturing activities, with a primary focus on CDMO business management, manufacturing performance governance, readiness and growth planning, cost of goods oversight, and scenario-based business decision support. This individual represents the business position for assigned product(s) across governance forums and key cross-functional decision-making bodies. The role ensures that product business requirements are translated into manufacturing priorities, performance expectations, contractual frameworks, and long-range network planning. The Senior Director will work across CMTO and partner functions to support continuity of supply, cost performance, operational readiness, and strategic manufacturing decision-making. Key Duties and Responsibilities: Serve as the Business Operations lead for assigned product(s) within CMTO, providing product-level business leadership across commercial manufacturing activities. Act as the business lead in the CDMO relationship, ensuring business priorities, risks, and requirements are appropriately represented and managed. Lead the product-level business position in governance forums related to manufacturing performance against established KPIs. Define and communicate business requirements for readiness and growth, and monitor progress to plan, including support for new vendor selection and manufacturing network changes as needed. Maintain end-to-end business understanding of CDMO and site performance for assigned product(s), including performance trends, risks, opportunities, and implications to product strategy. Establish, monitor, and evolve product-level KPIs with a focus on cost, efficiency, service, and operational performance. Develop and maintain performance dashboards and related management reporting to support governance, business reviews, and decision-making. Own responsibility for COGM, including establishing cost expectations over time, assessing key cost drivers, and tracking progress against COGM reduction plans. Drive product-level business decisions informed by manufacturing performance, including capacity, sourcing, continuity, supply risk, and network considerations. Partner with Strategic Sourcing, Manufacturing Operations, Legal, and Finance to develop and implement contract structures that align to the priorities and requirements of supported product(s). Lead and support commercial manufacturing scenario planning in support of DST, enterprise, and manufacturing assessments, including scenarios driven by scale, geopolitical changes, supply risk, or evolving business strategy. Translate strategic priorities into actionable plans with defined milestones, decision points, accountabilities, and measures of success. Identify and escalate business risks, dependencies, and execution gaps, and recommend actions to support timely and effective decision-making. Prepare executive-level materials, recommendations, and business updates for leadership reviews, governance discussions, and strategic planning processes. Contribute to the ongoing development of business operations processes, tools, and governance frameworks that strengthen execution across CMTO. Knowledge and Skills: Significant experience in biotechnology, pharmaceutical, or other highly regulated industry. Demonstrated experience supporting manufacturing, external manufacturing, CDMO management, or technical operations business processes. E xperience with product-level business management in a manufacturing environment, including governance, cost oversight, performance monitoring, and cross-functional decision support. Proven experience with COGM assessment, tracking, and cost improvement planning. Experience leading or contributing to governance forums tied to manufacturing performance, supply strategy, and business risk. Demonstrated ability to operate effectively in a matrixed environment and influence cross-functional stakeholders without direct authority. Strong business acumen with the ability to connect operational performance to product strategy, financial outcomes, and enterprise priorities. Excellent written, verbal, and presentation communication skills, including the ability to develop materials for senior leadership. Strong analytical and problem-solving skills, with ability to synthesize complex information into clear business recommendations. CDMO relationship and business management Product-level manufacturing governance KPI development and performance management Dashboard development and business reporting COGM modeling, tracking, and reduction planning Scenario planning and strategic assessment support Contracting partnership across sourcing, legal, and finance Capacity, sourcing, continuity, and supply risk evaluation Cross-functional planning and execution Strong proficiency in Microsoft Excel, PowerPoint, Word, and Teams Experience with enterprise and reporting tools such as SAP, Power BI, Tableau, Smartsheet, or similar systems Experience supporting external manufacturing networks and vendor selection processes Working knowledge of cGMP manufacturing environments Experience developing business cases and decision frameworks for manufacturing network, supply, or cost-related decisions Strong financial acumen and ability to partner effectively with Finance on product and manufacturing-related analyses Experience supporting global manufacturing or supply organizations Education and Experience: <s